Negative regulation of photoreceptor cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of photoreceptor cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NT5DC1, YES1, and CDK6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NT5DC1 grouped by Negative regulation of photoreceptor cell differentiation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NT5DC1 →	+0.207	+1.062	.006	.004	3	4
CNS	YES1 →	+0.170	+0.639	<.001	.002	3	4
LARGE_INTESTINE	CDK6 →	+0.227	+0.245	.005	.002	3	4
SKIN	PLPPR5 →	+0.158	+0.667	.005	.006	3	4
BREAST	FOXA1 →	-0.639	-0.786	<.001	.008	3	3
LUNG_NSCLC_LUAD	SPON2 →	-0.232	-1.544	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NT5DC1 by Negative regulation of photoreceptor cell differentiation activity — SOFT_TISSUE

Explore this box plot interactively →