Photoreceptor cell differentiation

Across TCGA cell cohorts, RNA activity of the Photoreceptor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AHNAK2, HTATIP2, and ZRANB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AHNAK2 grouped by Photoreceptor cell differentiation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	AHNAK2 →	-2.809	-1.681	.009	.002	3	6
CNS	HTATIP2 →	-1.912	-0.686	.003	.002	3	4
BONE	ZRANB2 →	+1.070	+1.928	.008	<.001	3	4
SOFT_TISSUE	IFITM1 →	+3.573	+1.046	<.001	.003	3	4
OESOPHAGUS	TAS2R42 →	+0.090	+1.047	.001	.002	3	4
LIVER	VPS37C →	+0.817	+1.394	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AHNAK2 by Photoreceptor cell differentiation activity — BONE

Explore this box plot interactively →