Photoreceptor cell differentiation

Across TCGA cell cohorts, RNA activity of the Photoreceptor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPRL3, ACO2, and RETREG2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Photoreceptor cell differentiation activity versus NPRL3 in BLOOD_Leukemia (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NPRL3 →	+0.461	+0.198	.006	.001	3	4
BONE	ACO2 →	+0.717	+0.349	.004	.001	3	4
CNS	RETREG2 →	+0.454	+0.175	.005	.001	3	4
LIVER	GTF2H3 →	-0.694	-0.308	.006	.001	3	4
SOFT_TISSUE	PSMA3 →	-0.594	-0.422	.005	.009	3	3
LUNG_NSCLC_LUAD	PTOV1 →	+0.763	+0.186	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046530 vs NPRL3 — BLOOD_Leukemia

Explore this scatter interactively →