Sphingoid metabolic process

Across TCGA patient cohorts, RNA activity of the Sphingoid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYBBP1A, RIF1_S782, and SNRPB2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingoid metabolic process activity versus MYBBP1A in BRCA (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MYBBP1A →	-0.465	-0.041	<.001	<.001	3	7
BRCA	RIF1_S782 →	-0.722	-0.038	<.001	.001	3	6
GBM	SNRPB2 →	-0.341	-0.061	<.001	<.001	3	6
GBM	TOP1 →	-0.333	-0.051	<.001	.001	3	6
BRCA	TSR1 →	-0.304	-0.035	<.001	<.001	3	6
GBM	SNRPG →	-0.367	-0.054	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046519 vs MYBBP1A — BRCA

Explore this scatter interactively →