Sphingoid metabolic process

Across TCGA patient cohorts, RNA activity of the Sphingoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGXB4, POP1, and NCL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingoid metabolic process activity versus HMGXB4 in GBM (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HMGXB4 →	-0.288	-0.216	.005	<.001	3	3
GBM	POP1 →	-0.309	-0.196	<.001	.001	3	3
GBM	NCL →	-0.188	-0.212	.003	<.001	3	3
GBM	RIOK1 →	-0.204	-0.155	.005	.003	3	3
GBM	AFF3 →	-0.689	-0.172	.009	.004	3	3
GBM	ACBD3 →	-0.210	-0.170	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046519 vs HMGXB4 — GBM

Explore this scatter interactively →