Sphingoid metabolic process

Across TCGA cell cohorts, RNA activity of the Sphingoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCA4, SUOX, and NECTIN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABCA4 grouped by Sphingoid metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ABCA4 →	+0.343	+1.299	.003	.002	3	4
URINARY_TRACT	SUOX →	-0.477	-1.613	.005	<.001	3	3
PANCREAS	NECTIN2 →	-0.863	-0.809	<.001	.009	3	3
CNS	WEE1 →	-0.567	-0.841	<.001	.002	3	3
BONE	ENTPD6 →	-1.046	-0.460	.002	.005	3	3
BONE	FRMD8 →	-0.886	-0.429	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABCA4 by Sphingoid metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →