Ceramide catabolic process

Across TCGA patient cohorts, RNA activity of the Ceramide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC25, GPSM2, and XPO7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ceramide catabolic process activity versus CCDC25 in LUAD (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CCDC25 →	-0.361	-0.146	<.001	.001	3	5
GBM	GPSM2 →	-0.568	-0.233	<.001	<.001	3	5
PDAC	XPO7 →	-0.183	-0.157	.001	<.001	3	5
LUAD	INTS9 →	-0.283	-0.111	<.001	.001	3	4
BRCA	CCAR2 →	-0.436	-0.160	.007	.005	3	4
LSCC	ZNF395 →	-0.541	-0.111	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046514 vs CCDC25 — LUAD

Explore this scatter interactively →