Ceramide catabolic process

Across TCGA patient cohorts, RNA activity of the Ceramide catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GLB1, PRKCD_S304, and PRKCD_T507, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ceramide catabolic process activity versus GLB1 in BRCA (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GLB1 →	+0.290	+0.178	<.001	<.001	3	5
UCEC	PRKCD_S304 →	+0.635	+0.206	<.001	<.001	3	4
GBM	PRKCD_T507 →	+0.846	+0.225	<.001	<.001	3	4
GBM	LUM →	+0.981	+0.231	<.001	<.001	3	4
GBM	PKN2_T816 →	+1.314	+0.303	<.001	<.001	3	4
GBM	PRKCI_T412 →	+0.913	+0.313	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046514 vs GLB1 — BRCA

Explore this scatter interactively →