Ceramide catabolic process

Across TCGA cell cohorts, RNA activity of the Ceramide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL28, SNX15, and CLCN5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLHL28 grouped by Ceramide catabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KLHL28 →	-0.633	-0.693	.001	.004	3	4
KIDNEY	SNX15 →	-0.843	-1.405	<.001	<.001	3	4
KIDNEY	CLCN5 →	-0.869	-1.037	<.001	.002	3	4
KIDNEY	TTC38 →	-1.041	-1.131	<.001	<.001	3	4
OVARY	SEC24A →	+0.492	+0.819	.009	.001	2	5
PANCREAS	FBXO24 →	-0.442	-1.296	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLHL28 by Ceramide catabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →