Ceramide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Ceramide biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BRIX1, EBNA1BP2, and G3BP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ceramide biosynthetic process activity versus BRIX1 in BRCA (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BRIX1 →	-0.457	-0.023	<.001	<.001	3	6
BRCA	EBNA1BP2 →	-0.356	-0.022	<.001	<.001	3	6
GBM	G3BP1 →	-0.293	-0.059	<.001	<.001	3	6
LSCC	CMSS1 →	-0.659	-0.044	<.001	<.001	3	6
GBM	NPC2 →	+0.508	+0.041	<.001	<.001	3	6
BRCA	PNISR →	-0.234	-0.014	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046513 vs BRIX1 — BRCA

Explore this scatter interactively →