Ceramide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Ceramide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC24A3-AS1, TRDMT1, and RBM22P4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ceramide biosynthetic process activity versus SLC24A3-AS1 in COAD (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SLC24A3-AS1 →	-0.062	-0.145	.002	.002	3	3
LSCC	TRDMT1 →	-0.348	-0.203	.007	.003	3	3
PDAC	RBM22P4 →	-0.191	-0.224	.007	.003	3	3
HNSC	THBS4 →	-1.760	-0.258	.001	<.001	3	3
HNSC	RCAN2 →	-0.597	-0.160	.001	.003	3	3
HNSC	ROR1 →	-0.657	-0.269	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046513 vs SLC24A3-AS1 — COAD

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