Ceramide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Ceramide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSBP3, TMEM63C, and CSGALNACT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SSBP3 grouped by Ceramide biosynthetic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SSBP3 →	-1.216	-1.167	<.001	.002	3	5
OESOPHAGUS	TMEM63C →	-1.496	-1.063	<.001	<.001	3	5
BREAST	CSGALNACT2 →	-0.712	-1.127	<.001	<.001	3	4
SKIN	RPL3L →	-0.080	-1.010	.005	.001	3	4
SKIN	AXL →	-3.365	-0.933	.002	.008	3	4
LUNG_NSCLC_LUAD	DMC1 →	-1.157	-1.011	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SSBP3 by Ceramide biosynthetic process activity — PANCREAS

Explore this box plot interactively →