Ceramide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Ceramide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PICALM, NFE2, and CFH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ceramide biosynthetic process activity versus PICALM in BLOOD_Leukemia (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PICALM →	+1.159	+0.852	<.001	.001	3	4
BLOOD_Leukemia	NFE2 →	+3.497	+1.202	<.001	<.001	3	4
CNS	CFH →	+3.596	+1.460	<.001	<.001	3	3
BLOOD_Leukemia	MINPP1 →	+2.167	+1.400	<.001	<.001	3	3
BLOOD_Lymphoma	CD72 →	-2.164	-0.856	.004	<.001	3	3
BLOOD_Lymphoma	C1RL →	+1.440	+0.741	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046513 vs PICALM — BLOOD_Leukemia

Explore this scatter interactively →