Sphingosine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Sphingosine biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THOC2, PRPF8, and SNRNP200, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingosine biosynthetic process activity versus THOC2 in GBM (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	THOC2 →	-0.302	-0.067	<.001	<.001	3	7
GBM	PRPF8 →	-0.233	-0.072	.001	<.001	3	7
GBM	SNRNP200 →	-0.256	-0.077	<.001	<.001	3	6
LSCC	CSE1L →	-0.286	-0.034	.001	.006	3	6
GBM	EFTUD2 →	-0.211	-0.071	.001	<.001	3	6
OV	GCN1 →	-0.236	-0.043	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046512 vs THOC2 — GBM

Explore this scatter interactively →