Sphingosine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Sphingosine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAPDHP1, RPL7P4, and RPL39P15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingosine biosynthetic process activity versus GAPDHP1 in BRCA (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GAPDHP1 →	-1.071	-0.688	.002	<.001	3	4
BRCA	RPL7P4 →	-0.358	-0.503	.005	.006	3	4
BRCA	RPL39P15 →	-1.658	-0.686	.001	<.001	3	4
COAD	SEC24D →	+0.452	+0.600	.008	.007	3	3
COAD	IMMP2L →	-0.364	-0.637	<.001	.001	3	3
BRCA	FKBP1C →	-0.759	-0.717	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046512 vs GAPDHP1 — BRCA

Explore this scatter interactively →