Sphingosine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Sphingosine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSC22D2, TRIR, and TMEM192, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingosine biosynthetic process activity versus TSC22D2 in BONE (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TSC22D2 →	+1.188	+0.251	.005	.002	3	4
STOMACH	TRIR →	-1.578	-0.246	.001	.003	3	4
STOMACH	TMEM192 →	+0.918	+0.235	.002	.006	2	5
BLOOD_Lymphoma	CYB561 →	+2.221	+0.964	.004	.007	3	4
SKIN	PSAP →	+0.829	+0.320	.001	<.001	3	4
BLOOD_Leukemia	GRAMD1B →	-1.625	-0.704	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046512 vs TSC22D2 — BONE

Explore this scatter interactively →