Glycerolipid catabolic process

Across TCGA patient cohorts, RNA activity of the Glycerolipid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACADSB, FUCA1, and STARD10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerolipid catabolic process activity versus ACADSB in BRCA (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACADSB →	+0.605	+0.026	<.001	<.001	3	7
BRCA	FUCA1 →	+0.669	+0.029	<.001	<.001	3	7
BRCA	STARD10 →	+0.962	+0.040	<.001	<.001	3	6
GBM	SUCLA2 →	+0.388	+0.037	<.001	<.001	3	6
BRCA	UTP4 →	-0.491	-0.033	<.001	<.001	3	6
PDAC	CRTAP →	-0.509	-0.046	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046503 vs ACADSB — BRCA

Explore this scatter interactively →