Glycerolipid catabolic process

Across TCGA patient cohorts, RNA activity of the Glycerolipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRPPA-AS1, KCNK6, and CD28, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerolipid catabolic process activity versus CRPPA-AS1 in PDAC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CRPPA-AS1 →	-0.307	-0.144	.008	.004	3	5
HNSC	KCNK6 →	+0.658	+0.168	.003	.005	3	4
GBM	CD28 →	+0.573	+0.186	.002	.001	3	4
GBM	S1PR4 →	+0.391	+0.163	.007	.003	3	4
GBM	CLEC10A →	+0.668	+0.169	.002	.005	3	4
GBM	CD52 →	+0.891	+0.195	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046503 vs CRPPA-AS1 — PDAC

Explore this scatter interactively →