Glycerolipid catabolic process

Across TCGA cell cohorts, RNA activity of the Glycerolipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM170B, AMDHD2, and APBA3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM170B grouped by Glycerolipid catabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TMEM170B →	-0.665	-0.670	.004	.004	3	3
PANCREAS	AMDHD2 →	+0.830	+0.363	<.001	.001	3	3
URINARY_TRACT	APBA3 →	+0.968	+0.313	.001	<.001	3	2
URINARY_TRACT	PHTF1 →	+0.961	+0.313	<.001	<.001	2	3
LUNG_NSCLC_LUSC	FKBP9 →	-1.573	-1.237	.009	.004	3	2
URINARY_TRACT	DDX31 →	+0.832	+0.304	.009	.008	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM170B by Glycerolipid catabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →