Protoporphyrinogen IX metabolic process

Across TCGA patient cohorts, RNA activity of the Protoporphyrinogen IX metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BRD8, CACYBP, and STK38, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protoporphyrinogen IX metabolic process activity versus BRD8 in HNSC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BRD8 →	+0.214	+0.069	<.001	.002	3	5
LSCC	CACYBP →	+0.386	+0.054	<.001	<.001	3	5
HNSC	STK38 →	-0.157	-0.047	<.001	.005	3	5
HNSC	PARP1 →	+0.333	+0.068	<.001	<.001	3	5
GBM	IQGAP1 →	-0.273	-0.028	.006	.004	3	5
HNSC	RPRD2_S374 →	+0.536	+0.079	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046501 vs BRD8 — HNSC

Explore this scatter interactively →