Protoporphyrinogen IX metabolic process

Across TCGA cell cohorts, RNA activity of the Protoporphyrinogen IX metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTN3A1, PTGR1, and BTN3A3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BTN3A1 grouped by Protoporphyrinogen IX metabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	BTN3A1 →	-1.355	-1.591	.006	.003	3	6
KIDNEY	PTGR1 →	-1.436	-1.465	.003	<.001	3	5
LUNG_NSCLC_LUSC	BTN3A3 →	-1.755	-1.681	.007	.001	3	4
LUNG_NSCLC_LUSC	RNF11 →	-1.055	-1.053	.003	.006	3	4
LUNG_NSCLC_LUSC	DNAJB5 →	-1.138	-1.123	.004	.003	3	4
LUNG_NSCLC_LUSC	IFITM3 →	-2.753	-1.135	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BTN3A1 by Protoporphyrinogen IX metabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →