S-adenosylmethionine metabolic process

Across TCGA patient cohorts, RNA activity of the S-adenosylmethionine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB40, ZC3H7A, and MYSM1, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, S-adenosylmethionine metabolic process activity versus ZBTB40 in DLBC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	ZBTB40 →	+1.084	+0.051	<.001	<.001	3	32
UVM	ZC3H7A →	+1.140	+0.047	<.001	<.001	3	31
UVM	MYSM1 →	+1.476	+0.049	<.001	<.001	3	31
DLBC	TRIM66 →	+0.719	+0.055	<.001	<.001	3	31
UVM	TNRC6A →	+0.999	+0.043	<.001	<.001	3	31
DLBC	PDPK1 →	+0.883	+0.054	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046500 vs ZBTB40 — DLBC

Explore this scatter interactively →