S-adenosylmethionine metabolic process

Across TCGA patient cohorts, RNA activity of the S-adenosylmethionine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AHCYL2, PEBP1, and MYSM1_S340, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, S-adenosylmethionine metabolic process activity versus AHCYL2 in LUAD (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AHCYL2 →	+0.683	+0.035	<.001	.001	3	6
BRCA	PEBP1 →	+0.404	+0.045	<.001	.001	3	5
LSCC	MYSM1_S340 →	+0.363	+0.036	<.001	.005	3	5
BRCA	MRI1 →	+0.318	+0.043	.002	<.001	3	5
BRCA	RSL1D1 →	-0.468	-0.046	.001	<.001	3	4
GBM	SEPTIN4 →	+0.787	+0.049	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046500 vs AHCYL2 — LUAD

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