S-adenosylmethionine metabolic process

Across TCGA patient cohorts, RNA activity of the S-adenosylmethionine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNA5SP496, RN7SKP134, and MIR1276, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, S-adenosylmethionine metabolic process activity versus RNA5SP496 in LSCC (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RNA5SP496 →	-0.559	-0.097	.004	.004	3	3
CCRCC	RN7SKP134 →	+0.538	+0.221	.005	<.001	3	3
CCRCC	MIR1276 →	-0.919	-0.155	<.001	.002	3	3
CCRCC	LSG1 →	-0.191	-0.128	.006	.001	3	3
OV	COMMD9 →	+0.402	+0.156	.002	<.001	3	2
OV	LRRC32 →	-0.747	-0.115	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046500 vs RNA5SP496 — LSCC

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