S-adenosylmethionine metabolic process

Across TCGA cell cohorts, RNA activity of the S-adenosylmethionine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYSF, EEF2, and SMARCB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, S-adenosylmethionine metabolic process activity versus DYSF in BONE (Pearson r = -0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DYSF →	-2.708	-0.363	<.001	.001	3	7
BONE	EEF2 →	+0.828	+0.335	.001	.004	3	5
BLOOD_Lymphoma	SMARCB1 →	+1.373	+0.244	<.001	<.001	3	5
LUNG_SCLC	POLR2D →	+0.605	+0.336	<.001	.001	3	5
BLOOD_Leukemia	NTHL1 →	+0.567	+0.106	.002	.008	3	5
BONE	TUFT1 →	-2.244	-0.414	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046500 vs DYSF — BONE

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