Phosphatidylinositol metabolic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylinositol metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, YME1L1, and RPL10A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol metabolic process activity versus RPL5 in OV (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPL5 →	-0.221	-0.032	.001	.004	3	9
BRCA	YME1L1 →	-0.357	-0.025	<.001	<.001	3	9
BRCA	RPL10A →	-0.204	-0.024	.004	<.001	3	8
CCRCC	RPS2 →	-0.218	-0.026	.001	<.001	3	8
GBM	SEPTIN4 →	+0.491	+0.020	<.001	.003	3	8
LUAD	CLPX →	-0.282	-0.028	.002	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046488 vs RPL5 — OV

Explore this scatter interactively →