Phosphatidylinositol metabolic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylinositol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENKD1, NFKBIL1, and C22orf23, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol metabolic process activity versus ENKD1 in LSCC (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ENKD1 →	-0.960	-2.066	.003	<.001	3	3
BRCA	NFKBIL1 →	-0.618	-0.763	<.001	.004	3	3
LSCC	C22orf23 →	-0.783	-2.066	.001	<.001	3	3
LSCC	CCDC102A →	-0.725	-2.063	.003	<.001	3	3
LSCC	TRAV22 →	+1.008	+1.789	.008	.008	3	3
BRCA	TMCO6 →	-0.427	-0.758	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046488 vs ENKD1 — LSCC

Explore this scatter interactively →