Phosphatidylinositol metabolic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APEX2, GNB2, and HOXB13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APEX2 grouped by Phosphatidylinositol metabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	APEX2 →	+0.750	+1.354	.007	<.001	3	3
BLOOD_Leukemia	GNB2 →	+0.640	+1.027	.004	.003	3	3
LARGE_INTESTINE	HOXB13 →	+0.919	+0.704	.008	.007	3	3
LUNG_SCLC	MAK →	-0.974	-1.163	.007	.001	3	3
LUNG_NSCLC_LUAD	RSPH10B2 →	-0.075	-0.443	.005	.003	3	3
OVARY	ZNF503 →	-2.049	-1.070	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APEX2 by Phosphatidylinositol metabolic process activity — KIDNEY

Explore this box plot interactively →