Phosphatidylinositol metabolic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF713, RHOU, and TTC5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF713 grouped by Phosphatidylinositol metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF713 →	-0.305	-0.041	.005	.009	3	5
SKIN	RHOU →	+0.162	+0.032	.002	.009	3	4
CNS	TTC5 →	+0.345	+0.048	.002	.005	3	4
CNS	CARS1 →	-0.181	-0.020	.001	.008	3	4
CNS	AWAT2 →	-0.215	-0.023	.006	.007	3	4
UPPER_AERODIGESTIVE_TRACT	LRRC75B →	+0.151	+0.048	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF713 by Phosphatidylinositol metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →