Phosphatidylinositol metabolic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAD23A, URB2, and PCDHB2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAD23A grouped by Phosphatidylinositol metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RAD23A →	-0.208	-0.737	.007	.006	2	4
LUNG_NSCLC_LUAD	URB2 →	+0.270	+1.001	.001	<.001	3	3
STOMACH	PCDHB2 →	-0.346	-1.539	<.001	<.001	3	3
STOMACH	RNF20 →	-0.281	-1.374	.002	<.001	3	3
SKIN	QARS1 →	-0.299	-0.992	.002	.001	3	3
LUNG_NSCLC_LUAD	MOSMO →	+0.300	+1.151	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAD23A by Phosphatidylinositol metabolic process activity — CNS

Explore this box plot interactively →