Glyoxylate metabolic process

Across TCGA patient cohorts, RNA activity of the Glyoxylate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP45_S619, CD53, and DOCK8, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glyoxylate metabolic process activity versus ARHGAP45_S619 in LSCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARHGAP45_S619 →	+0.799	+0.132	<.001	<.001	3	8
OV	CD53 →	+0.604	+0.062	<.001	.005	3	7
LSCC	DOCK8 →	+0.446	+0.109	<.001	<.001	3	7
HNSC	PTPN7 →	+0.476	+0.149	<.001	<.001	3	7
HNSC	GIMAP4 →	+0.627	+0.116	<.001	<.001	3	7
LSCC	SASH3 →	+0.412	+0.103	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046487 vs ARHGAP45_S619 — LSCC

Explore this scatter interactively →