Glyoxylate metabolic process

Across TCGA patient cohorts, RNA activity of the Glyoxylate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASP12, KPNA2, and CCNE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glyoxylate metabolic process activity versus CASP12 in UCEC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CASP12 →	+0.443	+0.097	.005	.004	3	5
LSCC	KPNA2 →	-0.785	-0.143	<.001	<.001	3	5
UCEC	CCNE1 →	-0.807	-0.102	.005	.002	3	4
UCEC	PDE1A →	+0.617	+0.169	.006	.001	3	4
UCEC	WDR45B →	-0.562	-0.097	<.001	.003	3	4
UCEC	RGS7BP →	+0.887	+0.120	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046487 vs CASP12 — UCEC

Explore this scatter interactively →