Glyoxylate metabolic process

Across TCGA cell cohorts, RNA activity of the Glyoxylate metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC22A13, KNDC1, and ALAS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC22A13 grouped by Glyoxylate metabolic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLC22A13 →	+0.448	+0.304	.003	.002	3	6
OVARY	KNDC1 →	-0.262	-0.181	.003	.006	3	5
CNS	ALAS2 →	-0.182	-0.298	<.001	<.001	3	5
LUNG_SCLC	AP4E1 →	-0.306	-0.301	.001	.005	3	5
BLOOD_Leukemia	ZBTB16 →	+0.191	+0.129	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	LCOR →	-0.138	-0.287	.009	.004	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC22A13 by Glyoxylate metabolic process activity — SOFT_TISSUE

Explore this box plot interactively →