Glyoxylate metabolic process

Across TCGA cell cohorts, RNA activity of the Glyoxylate metabolic process pathway is significantly associated with the drug response of multiple features, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Staurosporine, Talazoparib, and UNC0642, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Staurosporine grouped by Glyoxylate metabolic process-low versus -high activity in LIVER.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Staurosporine →	-1.490	-1.411	.045	.002	2	1
LIVER	Talazoparib →	-0.693	-1.411	.042	.002	2	1
LIVER	UNC0642 →	-0.225	-1.520	<.001	.001	2	1
LIVER	Mitoxantrone →	-1.476	-1.411	.046	.002	2	1
LIVER	Vincristine →	-1.415	-1.520	.027	.001	2	1
LIVER	765771 →	-1.335	-1.520	.012	.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Staurosporine by Glyoxylate metabolic process activity — LIVER

Explore this box plot interactively →