Glycosphingolipid catabolic process

Across TCGA patient cohorts, RNA activity of the Glycosphingolipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP22, TDRD10, and XPO7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosphingolipid catabolic process activity versus ARHGAP22 in CCRCC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ARHGAP22 →	+0.521	+0.259	<.001	<.001	3	4
CCRCC	TDRD10 →	+0.473	+0.239	<.001	<.001	3	4
BRCA	XPO7 →	-0.461	-0.179	.003	<.001	3	4
GBM	LYL1 →	+0.528	+0.249	.005	<.001	3	4
LSCC	MANBA →	+0.395	+0.121	.001	.003	3	4
GBM	VENTX →	+1.081	+0.279	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046479 vs ARHGAP22 — CCRCC

Explore this scatter interactively →