Glycosphingolipid catabolic process

Across TCGA cell cohorts, RNA activity of the Glycosphingolipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOL9, RANBP1, and C1orf174, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOL9 grouped by Glycosphingolipid catabolic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NOL9 →	-0.586	-1.229	<.001	<.001	3	5
BLOOD_Myeloma	RANBP1 →	-1.107	-0.449	.008	<.001	3	5
KIDNEY	C1orf174 →	-0.822	-1.270	.003	<.001	3	4
PANCREAS	C7orf61 →	-0.493	-1.093	.008	.002	3	4
BREAST	CDC14A →	-0.496	-0.557	.002	.008	3	4
KIDNEY	RTCB →	-0.667	-0.885	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOL9 by Glycosphingolipid catabolic process activity — SOFT_TISSUE

Explore this box plot interactively →