Glycosphingolipid catabolic process

Across TCGA cell cohorts, RNA activity of the Glycosphingolipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUMF1, TMED9, and CTSA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosphingolipid catabolic process activity versus SUMF1 in BONE (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SUMF1 →	+1.364	+1.743	<.001	<.001	3	8
BONE	TMED9 →	+1.593	+1.805	<.001	.002	3	7
LUNG_SCLC	CTSA →	+1.707	+1.516	<.001	<.001	3	6
BONE	HEXB →	+1.975	+1.618	<.001	.001	3	6
OESOPHAGUS	NEU1 →	+0.902	+0.770	.003	.004	3	6
BONE	CBX2 →	-2.016	-1.892	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046479 vs SUMF1 — BONE

Explore this scatter interactively →