Glycosylceramide catabolic process

Across TCGA patient cohorts, RNA activity of the Glycosylceramide catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TCIRG1, CBX8, and DMXL2_S1151, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosylceramide catabolic process activity versus TCIRG1 in GBM (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TCIRG1 →	+0.731	+0.126	<.001	<.001	3	6
GBM	CBX8 →	-0.569	-0.110	<.001	<.001	3	6
CCRCC	DMXL2_S1151 →	+0.470	+0.043	<.001	.002	3	6
GBM	IFI30 →	+0.884	+0.097	<.001	<.001	3	6
GBM	TLR2 →	+0.699	+0.113	<.001	<.001	3	6
GBM	MYO1F →	+0.857	+0.115	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046477 vs TCIRG1 — GBM

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