Glycosylceramide catabolic process

Across TCGA cell cohorts, RNA activity of the Glycosylceramide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNN, AK1, and KIF18A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PNN grouped by Glycosylceramide catabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PNN →	-1.158	-1.536	<.001	.006	3	3
KIDNEY	AK1 →	-1.266	-1.423	.002	<.001	3	3
KIDNEY	KIF18A →	-0.853	-1.175	.003	.006	3	3
KIDNEY	NUP85 →	-0.501	-1.300	.005	.004	3	3
KIDNEY	NHSL1 →	-1.225	-1.973	<.001	<.001	3	3
KIDNEY	WRAP53 →	-0.565	-1.086	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PNN by Glycosylceramide catabolic process activity — KIDNEY

Explore this box plot interactively →