Phosphatidylcholine metabolic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylcholine metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G6, PPP1R3B, and TSPO, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLA2G6 grouped by Phosphatidylcholine metabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PLA2G6 →	-0.226	-1.098	<.001	<.001	3	6
BLOOD_Leukemia	PPP1R3B →	-0.296	-0.706	.001	.003	3	5
LUNG_NSCLC_LUAD	TSPO →	-0.145	-0.683	.004	.001	3	5
LUNG_NSCLC_LUAD	LPGAT1 →	-0.188	-0.850	.008	.005	3	5
LUNG_NSCLC_LUAD	ALX4 →	-0.086	-0.745	.004	.002	3	5
OESOPHAGUS	APOA2 →	-0.310	-1.423	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLA2G6 by Phosphatidylcholine metabolic process activity — PANCREAS

Explore this box plot interactively →