Phosphatidylcholine metabolic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylcholine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCSK5, CAV2, and LARGE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylcholine metabolic process activity versus PCSK5 in OVARY (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PCSK5 →	+2.547	+0.820	.001	.005	2	5
BREAST	CAV2 →	-3.144	-0.636	.001	.008	3	4
BLOOD_Lymphoma	LARGE1 →	+1.527	+0.164	<.001	.002	3	3
BLOOD_Leukemia	SH2B3 →	-0.818	-0.594	.003	.008	3	3
BLOOD_Leukemia	KLF9 →	-0.791	-0.497	.007	.001	3	3
BLOOD_Leukemia	WARS1 →	-1.647	-0.882	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046470 vs PCSK5 — OVARY

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