Platelet activating factor metabolic process

Across TCGA cell cohorts, RNA activity of the Platelet activating factor metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKACA, TERF2, and USP30, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet activating factor metabolic process activity versus PRKACA in OESOPHAGUS (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRKACA →	+0.984	+0.346	.003	.001	3	6
UPPER_AERODIGESTIVE_TRACT	TERF2 →	+0.524	+0.326	.002	.009	3	6
BLOOD_Leukemia	USP30 →	+0.409	+0.099	.009	.007	3	6
LUNG_SCLC	CDK5R1 →	+1.334	+0.173	<.001	.001	3	6
LUNG_SCLC	PSIP1 →	+1.309	+0.242	<.001	<.001	3	6
LIVER	NRGN →	+2.130	+0.352	.002	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046469 vs PRKACA — OESOPHAGUS

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