Membrane lipid catabolic process

pathway activity — cross-omics
GO:0046466Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Membrane lipid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRSF10, QKI, and ASAH1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACSRSF10 →-0.340-0.041<.001.00238
PDACQKI →+0.190+0.049.001<.00138
GBMASAH1 →+0.420+0.071<.001<.00138
GBMRIN3 →+0.421+0.100<.001<.00137
GBMSRSF3 →-0.232-0.076<.001<.00137
GBMTCERG1 →-0.235-0.076<.001<.00137
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration