Neutral lipid catabolic process

Across TCGA patient cohorts, RNA activity of the Neutral lipid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORL1, IKBIP, and MCF2L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutral lipid catabolic process activity versus SORL1 in LUAD (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SORL1 →	+0.523	+0.038	<.001	.005	3	6
CCRCC	IKBIP →	-0.452	-0.042	<.001	.005	3	6
PDAC	MCF2L →	+0.394	+0.065	<.001	<.001	3	6
GBM	P3H1 →	-0.540	-0.057	.003	<.001	3	6
CCRCC	PLOD2 →	-0.883	-0.048	.002	.002	3	6
BRCA	LRBA →	+0.301	+0.028	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046461 vs SORL1 — LUAD

Explore this scatter interactively →