Neutral lipid catabolic process

Across TCGA cell cohorts, RNA activity of the Neutral lipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK3, OLFML2B, and CNOT6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STK3 grouped by Neutral lipid catabolic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	STK3 →	+1.986	+1.891	.005	<.001	3	3
OVARY	OLFML2B →	+1.045	+1.179	.003	<.001	3	3
OVARY	CNOT6 →	+0.743	+0.937	.001	.008	2	4
OVARY	WDR33 →	+0.655	+0.966	<.001	<.001	3	3
BREAST	REXO4 →	+0.438	+0.526	.002	.003	3	3
OVARY	C1D →	+0.384	+0.751	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STK3 by Neutral lipid catabolic process activity — BLOOD_Lymphoma

Explore this box plot interactively →