Neutral lipid catabolic process

Across TCGA cell cohorts, RNA activity of the Neutral lipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPG2, CD82, and DNAJB11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutral lipid catabolic process activity versus HSPG2 in PANCREAS (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HSPG2 →	-2.099	-1.166	.004	.006	3	4
PANCREAS	CD82 →	-2.882	-1.418	.004	<.001	2	5
OESOPHAGUS	DNAJB11 →	-0.799	-0.745	.006	.007	3	4
KIDNEY	SLC35E4 →	-1.178	-0.323	.009	.007	3	3
URINARY_TRACT	UBE2J1 →	+1.152	+1.863	.006	<.001	3	3
LUNG_SCLC	TREX2 →	-0.559	-1.004	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046461 vs HSPG2 — PANCREAS

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