Neutral lipid catabolic process

Across TCGA cell cohorts, RNA activity of the Neutral lipid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FABP5, ACP1, and PSMD5, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutral lipid catabolic process activity versus FABP5 in URINARY_TRACT (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	FABP5 →	+3.732	+1.504	.001	.007	2	11
OESOPHAGUS	ACP1 →	+1.131	+0.734	<.001	.003	3	8
LARGE_INTESTINE	PSMD5 →	+0.620	+0.486	.003	.004	3	8
URINARY_TRACT	TXNDC17 →	+2.870	+1.434	.001	.009	3	7
BONE	UBA2 →	+1.042	+1.246	.001	.001	3	7
BONE	CCT3 →	+0.947	+1.485	.007	<.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046461 vs FABP5 — URINARY_TRACT

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