Prostanoid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Prostanoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, PTGS2, and PACERR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostanoid biosynthetic process activity versus PLA2G4A in UCEC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLA2G4A →	+1.894	+0.272	<.001	<.001	3	7
UCEC	PTGS2 →	+1.826	+0.272	<.001	<.001	3	6
UCEC	PACERR →	+0.733	+0.222	<.001	<.001	3	5
GBM	PTPN22 →	+0.654	+0.244	<.001	<.001	3	5
GBM	ALG1L10P →	-0.596	-0.187	.002	.004	3	5
LSCC	SLC1A1 →	+0.477	+0.120	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046457 vs PLA2G4A — UCEC

Explore this scatter interactively →