Prostanoid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Prostanoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBR1, LRRC40, and AKR1C1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostanoid biosynthetic process activity versus CBR1 in BREAST (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CBR1 →	+2.019	+0.142	.009	.001	2	10
LUNG_NSCLC_LUAD	LRRC40 →	-0.474	-0.103	.002	<.001	3	8
LUNG_NSCLC_LUAD	AKR1C1 →	+5.045	+0.154	<.001	<.001	3	6
SKIN	HLA-DRA →	+3.681	+0.094	<.001	<.001	3	6
KIDNEY	ZNF644 →	-0.713	-0.146	<.001	.003	3	6
LUNG_NSCLC_LUAD	GPBP1L1 →	-0.364	-0.098	.007	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046457 vs CBR1 — BREAST

Explore this scatter interactively →