Icosanoid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Icosanoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RB, JAML, and FPR1, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Icosanoid biosynthetic process activity versus CSF2RB in CHOL (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	CSF2RB →	+1.638	+0.049	<.001	<.001	3	32
LAML	JAML →	+1.695	+0.049	<.001	<.001	3	32
LAML	FPR1 →	+2.235	+0.058	<.001	<.001	3	32
CHOL	CSF2RA →	+1.984	+0.076	<.001	<.001	3	32
LAML	LILRB3 →	+1.598	+0.054	<.001	<.001	3	32
SARC	VSIR →	+1.539	+0.057	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046456 vs CSF2RB — CHOL

Explore this scatter interactively →